London's Pulse: Medical Officer of Health reports 1848-1972

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City of London 1933

[Report of the Medical Officer of Health for London, City of ]

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No. of Sample.Date of inoculation of Guinea Pig.Dirt.Date of Death.Post Mortem Findings.Result qua Tubercle.
1416th MarchTrace3rd MayNormalNegative.
1516th MarchTrace3rd MayNormalNegative.
1616th MarchTrace3rd MayNormalNegative.
1716th MarchTrace3rd MayNormalNegative.
1816th MarchTrace3rd MayNormalNegative.
1922nd MarchTrace5th AprilMiliary nodules in spleen and liver. Caseous right inguinal glands. No tubercle bacilli found. Culture grows gram negative bacilli. Pus from gland inoculated into another guinea-pig. (See 19a.)
19a13th AprilNil16th JuneNormalFrustrate.
2022nd MarchTrace4th MayNormalNegative.
2122nd MarchTrace4th MayNormalNegative.
2222nd MarchNil4th MayNormalNegative.
2322nd MarchTrace4th MaySmall caseous glands in right inguinal and lumbar regions. Tuberculosis of spleen. Early tuberculosis of liver. Tubercle bacilli demonstrated in spleen.Positive.
2422nd MarchTrace4th MayNormalNegative.
257th Oct.Nil22nd Nov.Tuberculous glands in right inguinal region. Early tuberculosis of spleen and liver. Tubercle bacilli demonstrated in spleen.Positive.
267th Oct.Nil22nd Nov.NormalNegative.
277th Oct.Nil22nd Nov.NormalNegative.
287th Oct.Trace22nd Nov.NormalNegative.
297th Oct.Nil22nd Nov.NormalNegative.
307th Oct.Nil22nd Nov.NormalNegative.
3110th Oct.Nil27 th Nov.NormalNegative.
3210th Oct.Trace27th Nov.NormalNegative.
3310th Oct.Trace27th Nov.NormalNegative.
3410th Oct.Nil27th Nov.NormalNegative.
3510th Oct.Nil27th Nov.NormalNegative.
3610th Oct.Nil27th Nov.NormalNegative.
3710th Oct.Nil1st Dec.NormalNegative.
3812 th Oct.Trace1st Dec.NormalNegative.
3912th Oct.Nil1st Dec.NormalNegative.
4012th Oct.Nil1st Dec.NormalNegative.
4112th Oct.Nil1st Dec.NormalNegative.
4212 th Oct.Nil1st Feb.Tuberculous glands in right inguinal and lumbar regions. Early tuberculosis of liver and advanced tuberculosis of spleen. Tubercle bacilli demonstrated in inguinal glands.Positive.
4317th Oct.Trace6th Dec.Large abscess in right inguinal region, containing coliform bacilli and streptococci. No other lesions.Negative.
4417th Oct.Nil6th Dec.NormalNegative.
4517th Oct.Trace6th Dec.NormalNegative.
4617th Oct.Nil30th Oct.NormalFrustrate.
4717th Oct.Nil6th Dec.NormalNegative.
4817th Oct.Nil27th Nov.NormalNegative.
498th Nov.Nil19th Dec.NormalNegative.
508th Nov.Nil19th Dec.NormalNegative.

"Dirt.— As regards dirt, about half the samples were clean, and half contained a trace, but none
could be considered objectionable.
"Tuberculosis.— Two samples (Nos. 8 and 11) were repetitions of samples found positive in
September last (viz., Nos. 2 and 43, 1932, respectively). In the first, the animal died within one week
of inoculation, and the experiment was therefore frustrate, and the second was again found to be
positive. As these samples were collected with bias, they have been excluded from the calculations.
"Three other animals died within one month, and have also been excluded. One of these (No. 19)
died 14 days after inoculation, and was found to have extensive disease of the internal organs. The
condition did not resemble tuberculosis, no tubercle bacilli could be demonstrated, and a second animal
inoculated with pus from a lymphatic gland, failed to develop tuberculosis in six weeks.
"Forty-four samples have, therefore, to be considered, and of these, five were found to contain
living tubercle bacilli, namely, 11.1 per cent."
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