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4.—Slight localised redness with squeamishness after 1st injection,
followed by more severe local but no general reaction to 2nd
injection.
5.—Temperature 101° F. on 2nd day after 1st injection, settling
within -24 hours, and localised redness and tenderness lasting to
4th day.
Local Reactions to T.A.F.—One adult complained of a severe
local reaction after 1st injection, with stiffness persisting for 4
days, and leaving slight redness at the end of 7 days.
Reactions to Primary Schick Test.—One boy had an Epileptiform
attack, with cyanosis and rigidity two minutes after test;
always a highly strung boy but no definite previous history. He
completed course of T.A.F. and subsequent Schick Test without
further mishap. Another boy fainted on leaving the Clinic, but
mother gave a history of frequent similar collapses. One complained
of slight general malaise and feeling out of sorts for 24
hours. In another child a transient Scarlatiniform rash appeared,
and in one child who showed an extremely strong positive reaction
there was an acute cervical adenitis, subsiding in 3-4 days.
Pseudo Reactions to Schick Test.—By reading tests at the end
of 7 days, it was not possible to note all pseudo reactions occurring,
and only 24 were recorded during the year. Of these, 2 occurred
in children under 5 years of age ; 10 between the ages of 5 and 10
years, and 12 at ages over 10 years. In one case, aged 10 years,
the reaction appeared in less than 24 hours, arm swollen, throat dry,
and, within 3 days, an urticarial rash of extremities, with temperature
up to 100° F. and slight cervical adenitis. The temperature
was still 99° F. at the end of 7 days, but there was at that time no
evidence of any local reaction to the Schick Test. A history of
asthma and hay fever was elicited from the parent.
Co-operation with General Practitioners.—Three children,
unable to attend by reason of Infectious Disease at home, received
doses of T.A.M. from their private practitioner.
Eleven children were Schick Tested following upon 3-injection
immunisation elsewhere or privately, and all were found to be
Schick negative.
Of 9 children treated privately with one injection of Alum
Precipitated Toxoid (A.P.T.) (brand unspecified) at varying times
during the previous 12 months, 8 were Schick negative. Of these 8,