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Reactions reported during course of treatment were few—0.59
per cent. to T.A.M. and 0.39 per cent. to T.A.F. They, are summarised
as follows:—
Local Reactions to T.A.M.—9 after 1st injection (one severe)
and 6 after 2nd. The severe case showed redness with swelling
and tenderness from shoulder to elbow, commencing after 48 hours,
and lasting for 5 days; child, however, never confined to bed.
There was no reaction to later injections. The remaining 14 cases
were very mild, with symptoms in no way corresponding with the
physical signs.
Focal Reactions to T.A.M.—Two cases of Axillary Adenitis in
children of same family, one to 1st, and one to 2nd injection, and
one case of " sore throat " after 2nd injection.
General Reactions to T.A.M.—One case of headache after first
injection accompanied by malaise and anorexia ; and one characterised
by the appearance of a scarlatiniform rash 4 to 5 days after
2nd injection, transient in nature and with no systemic disturbance.
Local and General Reactions to T.A.M.—All subsequent to 1st
injection, and none dangerous or alarming.
1.—Slight local effects with urticarial rash and cervical
adenitis. An asthmatic history was admitted at the next attendance,
and no complaint was made after subsequent injections
(T.A.F. given in this case).
2.—Nausea same evening, with vomiting and temperature of
101° F. next day and later redness of arm; had completely recovered
by 3rd day, and had no ill-effects from subsequent injections of
T.A.M.
3.—Following a pseudo positive reaction to primary Schick
Test, on day after 1st injection complained of dry throat, headache
and vomiting, with slight tenderness and localised redness, temperature
102° F. Next day temperature still 102° F, but tongue
moist and clean, appetite good, sleeping well and not complainingHe
had fully recovered by the end of 3 days. Further treatment
was cautiously given and injections of 0.3 cc, 0.6 cc, and 0.8 cc
with only a slight transient local reaction to the last sufficed to
produce a Schick negative response after 3 months.