London's Pulse: Medical Officer of Health reports 1848-1972

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Hints from the Health Department. Leaflet from the archive of the Society of Medical Officers of Health. Credit: Wellcome Collection, London

Croydon 1937

[Report of the Medical Officer of Health for Croydon]

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86
Administration of Anti-typhoid Serum (Felix).
A supply of serum was obtained from the Lister Institute,
through the kindness of Dr. Felix, who also gave full directions
as to its use.

Table: The serum was given in doses of 33 c.c. on three consecutive days, and 17 patients received the full course. Of these 12 recovered and 5 died.

The serum was given in doses of 33 c.c. on three consecutive days, and 17 patients received the full course. Of these 12 recovered and 5 died.

Case.Day when adminstn. commenced.Immediate Reaction.Result.
1. D.G.8th dayRigors and vomiting about 2 hours after each injection with rise of temperature.Temperature came down for 3 days after injections. Died from heart failure on 24-11-37.
2. J.T. 28 yrs. (M.)24th dayNil except profuse perspiration after injection; no rise of temperature.No effect. Died 10 days after last injection.
3. J.B. 14 yrs. (M.)24th dayVomited after first injection and T. 103° rigor and T.1030 after second.Good effect, nervous symptoms, delirium and restlessness improved steadily.
4. A.W. 31 yrs. (M.)3rd dayShivering and temperature 103.2° after 2nd injection.No effect.
5. K.H. 10 yrs. (M.)7th dayTemperature 104° after 2nd injection and 103.8° after 3rd ininjection.No effect.
6. M.I. 24 yrs. (M.)11th dayRise of temperature 103° after first injection, rigor and T. 104° after 2nd.Good effect, temperature came down to normal 6 days after last injection.
7. H.R. 10 yrs. (M.)4th dayNil; temperature keeping high constantly.No effect. Died from toxemia and meteor-ism 6 days after last injection.
8. P.H. 12 yrs. (M.)5th dayNil.Improved, toxemia steadily diminished.
9. L.P. 31 vrs. (F.)9th dayTemperature 103.° after 3rd injection.No effect.
10. A.G 33 vrs. (M.)6th dayShivering with rise of temperature after each injection.No effect.