Chromatogram prints [2]

Date:
1951
Reference:
PP/GRW/B/8
Part of:
Wyatt, Gerard R. (1925-)
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Collection contents

Available online

view Chromatogram prints [2]

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In copyright

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Credit

Chromatogram prints [2]. In copyright. Source: Wellcome Collection.

About this work

Description

Several chromatogram prints showing separation of bases of hydrolysed nucleic acids. This file contains largely unlabelled data taken from the nucleic acids prepared from herring, bull and echinoderm sperm, viruses pathogenic to insects and bacteria, wheat germ, locusts and earthworms. Included in this file is a print of a paper chromatogram run with samples of herring sperm DNA (HNA) alongside supposed 5-methylcytosine (MC) isolated from the HNA, a deaminated form of MC (MC de-am.), synthetic 5-methylisocytosine (MisoC) and a deaminated form of MisoC (MisoC de-am). The unknown is MC, and this run provides considerable support for the hypothesis that MC is 5-methylcytosine. These results were used in Wyatt's 1951 paper "Recognition and Estimation of 5-methylcytosine in Nucleic Acids" published in The Biochemical Journal , showing how the substance had been characterised and estimated.

Publication/Creation

1951

Physical description

1 file c. 20 large chromatogram prints

Arrangement

Order as found.

Related material

Within this collection: PP/GRW/A/3; PP/GRW/A/4; PP/GRW/A/5; PP/GRW/B/1; PP/GRW/B/6

Location of duplicates

A digitised copy is held by Wellcome Collection as part of Codebreakers: Makers of Modern Genetics.

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