Clinical disorders of porphyrin metabolism. Part 1.

London : University of London Audio-Visual Centre, 1972.

1 encoded moving image (40.31 min.) : sound, black and white.

00:40:31

University of London

Restricted

In English

Presented by Professor Abe Goldberg, University of Glasgow. Introduced by Ian Gilliland. Produced by Peter Bowen. Made by University of London Audio-Visual Centre. Made for British Postgraduate Medical Federation.

This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded; all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.

Segment 1 Gilliland introduces Goldberg. Goldbert shows a picture of a female patient lying in a hospital bed and tells her case history. Time start: 00:00:00:00 Time end: 00:06:11:15 Length: 00:06:11:15

Segment 2 Goldberg talks in detail about the chemical properties of porphobilinogen and haem. He then refers to a slide detailing the different presentations of porphyria. Time start: 00:06:11:15 Time end: 00:09:46:00 Length: 00:03:35:00

Segment 3 Goldberg shows a bar chart detailing the different presenting symptoms of porphyria. He then shows a slide which reveals the course of porphyria and a diagram detailing the clinical manifestations of the disease. Time start: 00:09:46:00 Time end: 00:15:36:00 Length: 00:05:50:00

Segment 4 We see a picture of a patient with paresis of the hands. Goldberg refers to slides of photomicrographs of specimens from patients with porphyria. Time start: 00:15:36:00 Time end: 00:20:03:00 Length: 00:04:27:00

Segment 5 Goldberg shows a graph illustrating the effects of various barbiturates on ALA synthetase activity. He discusses the efficacy of various drugs on ALA activity. Time start: 00:20:03:00 Time end: 00:25:16:00 Length: 00:05:13:00

Segment 6 Goldberg talks about the gender and age factors that make porphyria more likely to occur. He shows graphs and charts which measure these factors. Time start: 00:25:16:00 Time end: 00:29:29:00 Length: 00:04:13:00

Segment 7 We see a photograph of a mother, baby and child. The mother had had porphyria but has survived and leads a good life.He then discusses four out of his thirty patients in a twenty year follow upstudy, who died. Time start: 00:29:29:00 Time end: 00:34:32:14 Length: 00:05:03:14

Segment 8 We see a slide of an intubated male patient who has had an acute attack of porphyria and is lying in a hospital bed, intubated. Goldberg describes the typical treatment for acute porphyria. Time start: 00:34:32:14 Time end: 00:40:31:14 Length: 00:05:59:14