Immunity and immunopathology.

London : University of London Audio-Visual Centre, 1974.

1 encoded moving image (32.18 min.) : sound, black and white.

00:32:18

University of London

Unrestricted

CC-BY-NC

Creative Commons Attribution-Non-Commercial 2.0 UK: England & Wales

In English

Presented by Dr AC Allison, Clinical Research Centre, Northwick Park. Produced by Peter Bowen and David Sharp. Made for British Postgraduate Medical Federation. Made by University of London Audio-Visual Centre.

This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded; all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.

Segment 1 Allison begins the lecture by outlining different kinds of immunity - innate and acquired. He refers specifically to immunity to polio, which is not innate in humans, but is in some monkey species, for example. Allison shows a table listing different immune responses of the body when fighting infection. He refers to immunodeficiency and shows a table listing the results of an experiment to artifically creat immunodeficiency in animals. Time start: 00:00:00:00 Time end: 00:06:18:08 Length: 00:06:18:08

Segment 2 Allison continues to discuss immunodeficiency. He refers to the research of professor Soothill which looks in detail at natural immunodeficiencies. He uses tables and charts to lay out the complex differences in different types of immunodeficiency, comparing in particular the differences between defective immunoglobulin levels and cell-mediated immunity. Time start: 00:06:18:08 Time end: 00:11:53:20 Length: 00:05:35:12

Segment 3 Allison moves on to discuss in detail what happens when antibodies and cells rise up against virus infections. He refers to a series of diagrams to illustrate his points. He discusses, in particular, the role of phagocytosis (foreign cell digestion). Time start: 00:11:53:20 Time end: 00:15:16:00 Length: 00:03:22:05

Segment 4 Allison turns to discuss the role of phagocytosis in the body's fight against bacterial, rather than viral, infections. He admits that the process by which both viral and bacterial infections are inactivated in cells is largely unknown; he discusses several possible hypotheses which attempt to explain this. Time start: 00:15:16:00 Time end: 00:21:37:00 Length: 00:06:21:00

Segment 5 Allison refers specifically to polio. He shows how the body's immune system attempts to fight off or at least stunt, the progress of destruction the virus will otherwise enact. He discusses how immunoglobulins can be passed from parents to children, referring to examples from animal studies. Time start: 00:21:37:00 Time end: 00:27:12:00 Length: 00:05:35:00

Segment 6 Allison discusses other virus types, each of which are attacked by the body's immune system in a different way. He shows a series of photomicrographs which compare infections in the cells of a normal and an immunosuppressed mouse. He concludes the lecture with a brief discussion of the specific role of T-lymphocytes. Time start: 00:27:12:00 Time end: 00:32:18:07 Length: 00:05:06:07