The molecular basis of ageing.

Date:
1974
  • Videos

About this work

Description

Here, Dr. Robin Holliday from the National Institute for Medical Research talks about ageing from the molecular point of view. He looks not only at the changes that occur in tissues as they age, but attempts to describe the mechamisms that give rise to these changes from a molecular level.

Publication/Creation

London : University of London Audio-Visual Centre, 1974.

Physical description

1 encoded moving image (25.52 min.) : sound, black and white.

Duration

00:25:52

Copyright note

University of London

Terms of use

Restricted

Language note

In English

Creator/production credits

Presented by Dr Robin Holliday. Introduced by Dr Ian Gilliland. Made by University of London Audio-Visual Centre. Made for British Postgraduate Medical Federation.

Notes

This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded; all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.

Contents

Segment 1 Gilliland introduces Dr Holliday. Holliday discusses the history of research into the field of ageing. Time start: 00:00:00:00 Time end: 00:05:14:15 Length: 00:05:14:15
Segment 2 Holliday shows photomicrographs of cultured cells, focusing on the cell count against time. He shows further cells taken from individuals of varying ages. He then shows photographs of a man with Werner's syndrome (progeria). Time start: 00:05:14:15 Time end: 00:10:18:20 Length: 00:05:04:05
Segment 3 Holliday compares the ageing of normal cells with those in conditions such as Werner's syndrome. Time start: 00:10:18:20 Time end: 00:15:08:20 Length: 00:04:50:00
Segment 4 Holliday turns to more detailed molecular research into enzymes connected with the ageing process. He shows a graph of the results of ageing cells in culture from a patient with Werner's syndrome. Time start: 00:15:08:20 Time end: 00:20:32:00 Length: 00:05:23:05
Segment 5 Holliday describes an experiment which doubles the speed of ageing of cells. Time start: 00:20:32:00 Time end: 00:25:52:24 Length: 00:05:20:24

Languages

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