Cancer immunology.

London : University of London Audio-Visual Centre, 1974.

1 encoded moving image (28.21 min.) : sound, black and white.

00:28:21

University of London

Unrestricted

CC-BY-NC

Creative Commons Attribution-Non-Commercial 2.0 UK: England & Wales

In English

Presented by Professor Hamilton Fairley, St Bartholomew's Hospital Medical School. Produced by Peter Bowen and David Sharp. Made for British Postgraduate Medical Federation. Made by University of London Audio-Visual Centre.

This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded; all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.

Segment 1 Fairley introduces the subject of the lecture and explains why one might expect to see antigens in malignant cells. He refers to an animal whose malignant cells were re-injected but which no longer grew into a tumour. Time start: 00:00:00:00 Time end: 00:05:27:21 Length: 00:05:27:21

Segment 2 Fairley shows a series of slides illustrating clinical signs of malignant melanoma. He refers in depth to an article by a plastic surgeon, Mr Bodenham, who showed evidence of cancer immunity occuring in the leg of a patient with malignant disease. Fairley then describes how antibodies against the tumour only occur in grade I and II disease. When the cancer has spread to become grade III, antibodies are no longer present. Time start: 00:05:27:21 Time end: 00:09:58:00 Length: 00:04:30:04

Segment 3 Fairley describes experiments in which lymphocyte cells have been shown to attack tumour cells. He then attempts to locate where in the body the immunological response occurs - evidence points to the fact that it is in the lymph nodes, leading Fairley to caution against removing cancer-free lymph nodes from women undergoing mastectomy. Time start: 00:09:58:00 Time end: 00:15:32:12 Length: 00:05:34:12

Segment 4 Fairley describes some problems with immunising against cancer cell proliferation; one of which being the fact that immunity doesn't last very long so repeated treatments would be necessary. Time start: 00:15:32:12 Time end: 00:20:00:00 Length: 00:06:27:12

Segment 5 Fairley talks in depth about an experiment by George Mathe in Paris which tested the immune responses of children with acute leukaemia. The results showed that those receiving immunotherapy treatments had a much better remission rate than those who didn't. Time start: 00:20:00:00 Time end: 00:24:35:00 Length: 00:04:35:00

Segment 6 Fairley continues to discuss the research of George Mathe on children with acute leukaemia. He refers to graphs and charts which detail the results of Mathe's work comparing other factors in terms of survival rate such as immune therapy plus chemotherapy combined. Fairley concludes the lecture by stressing that at the present time, immunotherapy can only be used in conjunction with radio and chemotherapy. Time start: 00:24:35:00 Time end: 00:28:21:21 Length: 00:03:46:21