Lymphokines.

London : University of London Audio-Visual Centre, 1976.

1 encoded moving image (49.56 min.) : sound, black and white

00:49:56

University of London

Unrestricted

CC-BY-NC

Creative Commons Attribution-Non-Commercial 2.0 UK: England & Wales

In English

Presented by Dr DC Dumonde, Head, Immunology Division, Kennedy Institute. Made for British Postgraduate Medical Federation. Made by University of London Audio-Visual Centre.

This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded; all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.

Segment 1 Dr Dumonde talks to camera and dramatically introduces the 'field of lymphokines.' He outlines what lymphokines our, pointing out their relation to immunology and delayed allergic hypersensitivity reactions. Dumonde looks back to the 1950s when the major break throughs in lymphokine research occurred; he shows photographs of different doctors involved in this research. Time start: 00:05:50:00 Time end: 00:05:50:00 Length: 00:05:50:00

Segment 2 Dumonde continues to look back at the history of lymphokine research. He describes the findings in detail, relating them also to breakthroughs in the medical understanding of the immune system. He shows a slide listing areas for investigation in the field of lymphokines and discusses, in particular, the biochemistry of lymphokines. Time start: 00:05:50:00 Time end: 00:10:00:00 Length: 00:04:10:00

Segment 3 Dumonde shows a photomicrograph demonstrating delayed hypersensitivity in an experiment on a guinea pig. He then discusses the effects of lymphokines on other cells such as macrophages, lymphocytes, polymorphs, fibroblasts and tumour cells. He refers to experiments in which lymphokines have been injected into different organs of the body and their effects on other cells recorded. Time start: 00:10:00:00 Time end: 00:14:33:00 Length: 00:04:33:00

Segment 4 Dumonde refers to slides showing various images of the lymphatic system, which he explains in detail, discussing in particular how lymphokines move around the body and interact with other cells along the way. Time start: 00:14:33:00 Time end: 00:18:18:18 Length: 00:03:45:18

Segment 5 A film clip is shown in which Dumonde is seen in a laboratory, talking over procedures in which scienists culture endothelial cells, separating out lymphocytes from pig blood. He describes what is seen and talks to a participating scientist who remains off screen. End of film clip. Time start: 00:18:18:18 Time end: 00:24:28:11 Length: 00:06:09:18

Segment 6 Dumonde shows a photomicrograph of endothelial cells and describes how they can be damaged by lymphokines. He then refers to a diagram showing how the hormone prostaglandin E acts on lymphocytes. Time start: 00:24:28:11 Time end: 00:29:34:00 Length: 00:05:05:14

Segment 7 Dumonde refers to experiments in which lymphokines have been experimentally injected into the ears of guinea pigs. he describes in detail what effect this has on the lymph nodes of the guinea pig. Time start: 00:29:34:00 Time end: 00:35:30:18 Length: 00:05:56:18

Segment 8 Dumonde introduces some of the latest experimental research into lymphokines, particularly with regard to the immune system. He describes different types of allergic reaction and highlights the role of lymphokines in these. Time start: 00:35:30:18 Time end: 00:39:47:00 Length: 00:04:16:07

Segment 9 Dumonde discusses the application of lymphokines to the study of autoimmune disorders. He then refers to how lymphokines can be measured, particularly their biological activity. He describes how bioassays can help in this process and shows a slide of a freeze-dried lymphokine sample. Time start: 00:39:47:00 Time end: 00:44:24:00 Length: 00:04:37:00

Segment 10 Dumonde concludes the lecture by discussing directions in which lymphokine research might go in the future. Time start: 00:44:24:00 Time end: 00:49:56:14 Length: 00:05:22:14